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Allergens

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Allergens -Drugs

  • 5-Aminosalicylicacid
  • Acetylsalicylic Acid (ASS)
  • Ambroxole
  • Amoxycillin
  • Ampicillin
  • Articaine
  • Benzocaine
  • Bupivacain
  • Carbocain
  • Cefalotin
  • Cefuroxime
  • Cephalosporin
  • Chloramphenicol
  • Ciprofloxacin
  • Clavulanic acid
  • Clindamycin
  • Cloxacillin
  • Cortison
  • Cyanocobalamin Vitamin B12
  • Dexamethasone
  • Diclofenac
  • Dipyron/Metamizole
  • Doxycyclin
  • Erythromycin
  • Gentamycin
  • Ibuprofen
  • Insulin human (Humalog)
  • Insulin human (Insuman Rapid)
  • Insulin human (Protaphane Penfill)
  • Lidocaine / Xylocain
  • Lincomycin
  • L-Tyroxine
  • Mepivacain
  • Metronidazole
  • Neomycin
  • Oxacillin
  • Paracetamol
  • Penicillamin
  • Penicilloyl G
  • Penicilloyl V
  • Piperacillin
  • Piroxicam
  • Prednisolone
  • Prilocaine
  • Pyrazolone (4-Amino-Antipyrine)
  • SMZ (Sulfamethoxazole)
  • Streptomycin
  • Tartrazin
  • Tetanus-Toxoide
  • Tetracycline
  • Theophylline / Aminophylline
  • TMP (Trimethoprime)
  • Tobramycin
  • Vitamin B6
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Allergens - Mites

  • Acarus siro
  • Blomia tropicalis
  • D. farinae
  • D. microceras
  • D. pteronyssinus
  • Euroglyphus maynei
  • Glycophagus domesticus
  • House Dust Mites (d1,d2)
  • Lepidoglyphus destructor
  • Mites - Mix 3 (d70,d71,d72,d73)
  • Mites - Mix 4 (d1,d2,d3,d4,d70,d71,d72,d73)
  • Tyrophagus putreus
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Allergens- Animals Epithellia

  • Animal Mix 13 (e1,e11,e80,e81)
  • Animal Mix 14 (e1,e3,e4,e5,e6)
  • Animal Mix 19 (e1,e4,e5,e70,e81,e88)
  • Bed Feathers (e70,e85,e86)
  • BSA Bovine Serum Albumine Cow
  • Budgerigar (Droppings)
  • Budgerigar (Feathers)
  • Budgerigar (Serum)
  • Cagebirds 7 (e14,e16,e51,e79)
  • Cagebirds Mix 11 (e9,e10,e50,e78)
  • Canary (Feathers)
  • Canary (Serum)
  • Cat (Dander)
  • Chicken (Feathers)
  • Chicken (Serum)
  • Chinchilla (Hair)
  • Cow (Dander)
  • Dog (Dander)
  • Dog (Hair)
  • Duck (Droppings)
  • Duck (Feathers)
  • Epithelia / Feathers (e3,e4,e70,e85)
  • Epithelia 1(e1,e3,e4,e5)
  • Epithelia 17 (e1,e3,e4,e5,e70,e81,e85)
  • Epithelia 18 (e1,e3,e5,e6,e82)
  • Epithelia 2 (e1,e5,e6,e84)
  • Epithelia 3 (e3,e4,e81,e82)
  • Feather 6 (e11,e70,e85,e86)
  • Finch (Droppings)
  • Finch (Feathers)
  • Goat (Dander)
  • Gold Hamster (Hair)
  • Goose (Droppings)
  • Goose (Egg White)
  • Goose (Feathers)
  • Guinea Pig (Hair)
  • Horse (Dander)
  • Mouse (Dander)
  • Mouse (Droppings)
  • Mouse (Protein + Dander)
  • Mouse (Serum)
  • Mouse (Urine)
  • Parrot (Droppings)
  • Parrot (Feathers)
  • Pig (Dander)
  • Pig (Serum)
  • Pigeon (Droppings)
  • Pigeon (Egg White)
  • Pigeon (Feathers)
  • Pigeon (Serum)
  • Rabbit (Hair)
  • Rabbit (Serum)
  • Rat (Dander)
  • Rat (Droppings)
  • Rat (Protein + Dander)
  • Rat (Serum)
  • Rat (Urine)
  • Rodents (e6,e71,e73,e82,e84)
  • Sheep (Dander)
  • Turkey (Feathers)
  • Wild Boar (Dander)
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Allergens - Food

  • Almond
  • Alpha - Lactalbumin
  • Alpha-Amylase
  • Amaranth
  • Anchovy
  • Apple
  • Apricot
  • Artichoke
  • Asparagus
  • Aubergine
  • Avocado
  • Banana
  • Barley flour
  • Beef
  • Beet Root
  • Beta - Lactoglobulin
  • Black Tea
  • Blue mussel
  • Blueberry
  • Brazil Nut
  • Broccoli
  • Brussels sprout
  • Buckwheat flour
  • Cabbage
  • Cacao
  • Camomile Tea
  • Carp
  • Carrot
  • Casein
  • Cashew Nut
  • Cauliflower raw
  • Celeriac
  • Cheddar Cheese
  • Cherry
  • Chicken meat
  • Chick-pea
  • Chocolate
  • Clam Shell
  • Coconut
  • Codfish
  • Codfish
  • Coffee
  • Corn (grain)
  • Corn flour
  • Cow´s milk (raw)
  • Crab
  • Cranberry
  • Cress
  • Crustaceae/Fish (f3,f24,f37,f40,f41)
  • Cucumber
  • Date
  • Duck meat
  • Eel
  • Egg (White & Yolk)
  • Egg White
  • Egg Yolk
  • Fennel
  • Fig
  • Flax Seed (bruised grain)
  • Flours 2 (f4,f5,f7,f79)
  • Food Screen (f1,f2,f3,f4,f13,f14,f44,f85)
  • Foods 4 (f1,f2,f4,f13,f14)
  • Fruit - Birch Pollen Ass. (f17,f49,f53,f73,f148)
  • Fruit 9 (f29,f33,f49,f53)
  • Fruit Latex Ass. (f29,f84,f91,f131,f149)
  • Garlic
  • Gluten
  • Goose meat
  • Grape
  • Grapefruit
  • Green bean
  • Green Tea
  • Hazelnut
  • Hering
  • Hop
  • Horseradish
  • Kiwi
  • Kohlrabi
  • Leek
  • Lemon
  • Lentil
  • Lettuce
  • Lobster
  • Macadamia Nut
  • Malt
  • Mango fruit
  • Maracuja
  • Meat 8 (f26,f27,f88)
  • Melon
  • Millet
  • Mould Cheese
  • Mushroom
  • Mutton/ Lamb
  • Nectarine
  • Nuts 1 (f13,f16,f17,f20)
  • Nuts 15 (f13,f17,f18,f20,f36)
  • Oat flour
  • Olive black
  • Olive green
  • Onion
  • Orange
  • Ovalbumin
  • Ovomucoid
  • Oyster
  • Papaya
  • Paprika
  • Parsley
  • Pea
  • Peach
  • Peanut
  • Pear
  • Pecan Nut
  • Peppermint
  • Pike
  • Pine nut, pignoles
  • Pineapple
  • Pistachio Nut
  • Plum
  • Poppy
  • Pork
  • Potato
  • Pumpkin seed
  • Rabbit
  • Raspberry
  • Redcurrant
  • Rice
  • Rosefish
  • Rye flour
  • Saccharomyces carlsbergensis
  • Salmon
  • Sesame (bruised grain)
  • Shrimp
  • Sole
  • Sorrel
  • Soy (bruised grain)
  • Soybean
  • Spinach
  • Spiny Lobster
  • Squid
  • Strawberry
  • Sunflowergrain
  • Sweet Chestnut
  • Swiss Cheese
  • Swordfish
  • Tangerine
  • Tofu
  • Tomato
  • Trout
  • Tuna
  • Turkey
  • Vanilla
  • Veal
  • Vegetable 5 (f12,f15,f31,f35)
  • Vegetable 6 (f25,f38,f39,f46)
  • Walnut
  • Wheat flour
  • White Bean
  • Yeast
  • Zucchini
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Allergens - Grasses

  • Bahia Grass
  • Barley
  • Bermuda Grass
  • Brome Grass
  • Canary Grass red
  • Common Reed
  • Corn
  • Corn Mix 4 (g12,g14,g15,g18,g20)
  • Couch Grass
  • Creeping Bentgrass
  • Cultivated Oat
  • Cultivated Rye
  • Dog's Tail Grass
  • Grass Mix 10 (g2,g4,g5,g6,g8,g14)
  • Grass Mix 11 (g3,g4,g5,g6,g8,g20)
  • Grass Mix 12 (g1,g2,g9,g10,g15)
  • Grass Mix 13 (g3,g4,g5,g6,g13)
  • Grass Mix 15 (g2,g3,g4,g5,g6,g8)
  • Grass Mix 17 (g2,g4,g5,g6,g10,g17)
  • Grass Mix 18 (g4,g5,g6,g21)
  • Grass Mix 19 (g6,g12,g14,g15,g18,g21)
  • Grass Mix 20 (g1,g3,g4,g5,g8)
  • Grass Mix 3 (g3,g4,g5,g8)
  • Grass Mix 5 (g1,g2,g5,g6,g10)
  • Grass Mix 6 (g2,g5,g6,g8,g10)
  • Grasses early (g3,g4,g5,g6,g8)
  • Grasses late (g1,g5,g7,g12,g13)
  • June Grass
  • Meadow fescue
  • Meadow foxtail
  • Oat Grass Tall
  • Orchard Grass
  • Perennial Rye Grass
  • Sudan Grass
  • Sweet Vernal Grass
  • Timothy Grass
  • Velvet Grass
  • Wheat
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Allergens - House Dusts

  • House Dust T/S (Hollister Stier) (e1,e5,d1,d2,m2,m3)
  • House Dust M (Bencard) (e1,e5,d1,d2,m2,m3)
  • House Mix (d1,d2,e1,e5,m2,m3)
  • House Mix 2 (d1,e1,e5,m3,m6)
  • House Mix 3 (d1,d2,i6,m1,m3,m5,m6)
  • House Dust Mix 1 (d1,d2,i6)
  • House Dust Mix 2 (d1,d2,e1,e5)
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Allergens - Insects

  • American Cockroach
  • Bumble Bee Venom
  • Fire Ant
  • Gadfly
  • German Cockroach
  • Honey Bee Venom
  • Hornet Venom
  • Housefly
  • Melittin
  • Mosquito
  • Paper Wasp
  • Phospholipase A (Honey Bee)
  • Red Midge Larva
  • Tribolium confusum
  • Wasp Venom
  • Waterflea
  • White (bald) faced Hornet
  • Yellow Hornet
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Occupational Allergens

  • Alcalase
  • Amyloglucosidase
  • Azorubin
  • Carmine red
  • Castor Bean
  • Collagen (animal, herbal)
  • Diphenyl methane MDI
  • Ethyleneoxide
  • Ficus benjamina
  • Green Coffee Bean
  • Gum arabic
  • Hexamethylene diisocyanate HDI
  • Latex (Hevea brasiliensis)
  • Lipoxigenase
  • Maxatase
  • Savinase
  • Silk (Bombyx mori)
  • Toluene diisocyanate TDI
  • Tomato red
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Moulds, Yeasts & Microoganisms

  • Alternaria tenuis (alternata)
  • Aspergillus amstelodami
  • Aspergillus flavus
  • Aspergillus fumigatus
  • Aspergillus nidulans
  • Aspergillus niger
  • Aspergillus oryzae
  • Aspergillus versicolor
  • Aureobasidium pullulans
  • Botrytis cinerea
  • Candida albicans
  • Cephalosporium acremonium
  • Chaetomium globosum
  • Cladosporium herbarum
  • Cladosporium spp.
  • Curvularia lunata
  • Epicoccum purpurascens
  • Epidermophyton floccosum
  • Fusarium moniliforme
  • Helminthosporium halodes
  • Microsporum canis
  • Mold Mix 11 (m1,m3,m5)
  • Mold Mix 12 (m1,m2,m3,m5,m6)
  • Mold Mix 14 (m1,m2,m3,m4,m5)
  • Mold Mix 15 (m6,m7,m8,m9,m16)
  • Mold Mix 17 (m1,m3,m5,m47,m56)
  • Mold Mix 2 (m11,m12,m22,m23)
  • Mold Mix 3 (m14,m20,m45)
  • Mold Mix 4 (m13,m24)
  • Mold Mix 5 (m4,m11,m20,m22)
  • Mold Mix 6 (m3,m40,m49)
  • Mold Mix 7 (m19,m33,m36)
  • Mold Mix 8 (m1,m25,m28,m30)
  • Mucor mucedo
  • Mucor racemosus
  • Mucor spinosus
  • Neurospora sitophila
  • Paecilomyces spp.
  • Penicillium brevicompactum
  • Penicillium chrysogenum (notatum)
  • Penicillium digitatum
  • Penicillium expansum
  • Penicillium roqueforti
  • Phoma betae
  • Rhizopus nigricans
  • Saccharomyces carlsbergensis
  • Saccharomyces cerevisiae
  • Saccharomyces ellipsoideus
  • Serpula lacrymans (Syn. Merulius lacrymans)
  • Stemphlium botryosum
  • Stemphylium botryosum
  • Thermoactinomyces candidus
  • Thermoactinomyces vulgaris
  • Trichoderma viride
  • Trichophyton mentagrophytes (Var. Interdigitale)
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Recombinant[R]native [N]

  • Alpha-Gal (galactose-alpha-1,3-galactose)
  • Alternaria alternata (Alt a1)
  • Apple (Mal d1)
  • Apple (Mal d3)
  • Birch (Bet v1)
  • Birch (Bet v2)
  • Birch (Bet v4)
  • Carrot (Dau c1)
  • Cat (Fel d1)
  • Chicken Egg (Gal d3)
  • Common Ragweed (Amb a1)
  • D. farinae (Der f1)
  • D. farinae (Der f2)
  • D. pteronyssinus (Der p1)
  • D. pteronyssinus (Der p10)
  • D. pteronyssinus (Der p2)
  • D. pteronyssinus (Der p23)
  • Haselnuss (Cor a14)
  • Hazel (Cor a1)
  • Hazelnut (Cor a1)
  • Hazelnut (Cor a8)
  • Hazelnut (Cor a9)
  • Honey bee venom (Api m1)
  • Honey bee venom (Api m10)
  • Honey bee venom (Api m2)
  • Horseradich (CCD)
  • Latex (Hev b5)
  • Latex (Hev b6)
  • Latex (Hev b8)
  • Mugwort (Art v1)
  • Olive (Ole e1)
  • Parvalbumin Carp (Cyp c1)
  • Peach (Pru p1)
  • Peach (Pru p3)
  • Peach (Pru p4)
  • Peanut (Ara h1)
  • Peanut (Ara h2)
  • Peanut (Ara h3)
  • Peanut (Ara h6)
  • Peanut (Ara h8)
  • Peanut (Ara h9)
  • Shrimp (Tropomyosin)
  • Strawberry (Fra a1)
  • Strawberry (Fra a3)
  • Timothy grass (Phl p1 + Phl p5)
  • Timothy grass (Phl p1)
  • Timothy grass (Phl p12)
  • Timothy grass (Phl p5)
  • Timothy grass (Phl p7 + Phl p12)
  • Timothy grass (Phl p7)
  • Wasp venom (Ves v5)
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Allergens - Spices

  • Aniseed
  • Balm
  • Basil
  • Beanstalk
  • Black Pepper
  • Caraway
  • Cardamom
  • Chervil
  • Chili
  • Chives
  • Cinnamon
  • Clove
  • Coriander
  • Curcuma
  • Curry
  • Dill
  • Food-Panel (f7,f18,f29,f38,f48,f51,f65,f70,f88)
  • Ginger
  • Green Pepper
  • Inhalation Panel 6 (d2,e1,e3,e5,m6)
  • Inhalation-Mix (d1,d2,ex6,e1,e5,m2,m3,m6)
  • Inhalation-Mix (g2,g4,g5,t11,t14,t15,t36,w9,w18)
  • Inhalation-Panel (t1,t8,t17,t28,w20,b14,b23,m22,m36)
  • Juniper berry
  • Laurel
  • Lovage
  • Mace
  • Marjoram
  • Nutmeg
  • Origan
  • Piment
  • Pollen / Molds (m3,m6,g12,g15)
  • Red Pepper
  • Red Pepper
  • Regional Mix (g6,w6,w9,w21,t3)
  • Rosemary
  • Sage
  • Screen Multi (g6,g12,t3,w6,d1,e1,e5,m2)
  • Screen Multi 10 (e1,e5,d1,d3,m2,m3)
  • Screen Multi 32 (d1,d2,e1,e5,g6,t3,t14,w6,w15,m6)
  • Screen perennial (d1,e1,e5,m3)
  • Screen Saisonal (g6,t3,w6,m6)
  • Spices 1 (s1,s2,s3,f47)
  • Spices 16 (s1,s2,s3,s6,f47)
  • Spices 2 (s4,s6,s7,f89)
  • Spices 3 (s5,s6,s7,f79)
  • Spices 4 (s1,s2,s3)
  • Spices 5 (s5,s6,s7)
  • Spices 71 (s3,s5,s16,s28)
  • Tarragon
  • Thyme
  • White Pepper
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Allergens - Trees

  • Acacia
  • Alder
  • Almond
  • Ash
  • Beech
  • Birch
  • Cedar
  • Cherry
  • Chestnut
  • Cypress
  • Datepalm
  • Elder
  • Elm
  • Eucalyptus
  • Fir
  • Fir tree
  • Hawthorn
  • Hazelnut
  • Japanese Cedar
  • Jasmin
  • Lilac
  • Lime Tree
  • Lombardy Poplar
  • Magnolia
  • Maple
  • Mesquite
  • Mimosa
  • Mulberry
  • Oak
  • Olive
  • Orange
  • Pecan
  • Pine
  • Plane
  • Poplar
  • Privet
  • Robinia
  • Sade Tree
  • Tea Tree
  • Thuja
  • Trees early (t2,t4,t8,t12,t14)
  • Trees late (t1,t3,t5,t7,t10)
  • Trees Mix 10 (t3,t7,t8,t9,t11,t12,t14)
  • Trees Mix 13 (t5,t7,t9,t12,t36,t40)
  • Trees Mix 14 (t2,t4,t8,t9,t12)
  • Trees Mix 15 (t3,t5,t7,t9,t10)
  • Trees Mix 16 (t7,t8,t11,t12,t14)
  • Trees Mix 17 (t3,t7,t8,t11,t16,t18,t19)
  • Trees Mix 18 (t3,t7,t8,t11,t18,t36,t40)
  • Trees Mix 19 (t3,t6,t7,t8,t30)
  • Trees Mix 20 (t2,t4,t7,t8,t14)
  • Trees Mix 21 (t3,t7,t9,t12,t14,t16)
  • Trees Mix 23 (t5,t7,t11,t14,t36)
  • Trees Mix 24 (t2,t4,t7,t8,t11,t12,t14)
  • Trees Mix 25 (t1,t3,t4,t7,t8,t14,t23)
  • Trees Mix 26 (t1,t2,t3,t7,t12,t14)
  • Trees Mix 27 (t2,t4,t7,t8,t10,t11,t12,t14)
  • Trees Mix 3 (t3,t7,t8,t24,t30)
  • Trees Mix 4 (t1,t3,t5,t7,t11,t14)
  • Trees Mix 5 (t1,t3,t7,t8,t28,t31)
  • Trees Mix 6 (t9,t11,t23)
  • Trees Mix 7 (t2,t3,t9)
  • Trees Mix 8 (t2,t3,t4,t7,t12)
  • Trees Mix 9 (t2,t3,t4,t5,t7,t8,t11,t12)
  • Walnut
  • White Pine
  • Willow
  • Yew
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Allergens - Weeds & Flowers

  • Acalee
  • Alfalfa
  • Amaranth
  • Arnica
  • Aster
  • Begonia
  • Camomile
  • Carnation
  • Chrysanthemum
  • Clover, sweet
  • Common Cucklebur
  • Common Ragweed
  • Dahlia
  • Dandelion
  • False Ragweed
  • Firebush
  • Flower Mix 13 (w7,w28,w36,w30)
  • Flower Mix 14 (w17,w22,w23,w40)
  • Flower Mix 4 (w7,w17,w22,w23)
  • Flower Mix 5 (w30,w35,w36,w40)
  • Geranium
  • Giant Ragweed
  • Golden bell
  • Goldenrod
  • Heather
  • Hibiscus
  • Hyacinth, blue
  • Lamb's Quaters
  • Lavender
  • Mallow
  • Marsh, elder rough
  • Mugwort
  • Narcissus
  • Nettle
  • Oleander
  • Ox Eye Daisy
  • Primerose
  • Rape
  • Ribwort Plantain
  • Rose
  • Rose of Sharon
  • Saltwort
  • Scale
  • Sorrel
  • Sunflower
  • Wall pellitory 1
  • Wall pellitory 2
  • Weed Mix 1 (w1,w6,w7,w8,w12)
  • Weed Mix 10 (w6,w9,w10,w11)
  • Weed Mix 11 (w1,w6,w9,w10,w19,w20)
  • Weed Mix 12 (w9,w10,w11,w19)
  • Weed Mix 2 (w9,w10,w11)
  • Weed Mix 3 (w6,w9,w10,w20)
  • Weed Mix 30 (w6,w9,w13,w18,w20,w21)
  • Weed Mix 6 (w1,w6,w9,w10,w11)
  • Weed Mix 7 (w6,w9,w10,w12)
  • Weed Mix 9 (w3,w6,w9,w10,w15,w20)
  • Western Ragweed
  • Willow herb
  • Wormwood
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Allergens - Elisa Kits

  • ANA Screen ELISA 
  • CENP-A ELISA
  • CENP-B ELISA
  • DsDna Elisa 
  • ENA Profile 8 Elisa 
  • Jo-1 ELISA
  • La ELISA
  • PM1-Alpha-ELISA
  • Reference System IgG
  • Reference System IgG4
  • Ribosomal P ELISA
  • RNP/Sm ELISA
  • Ro52 ELISA
  • Ro60 ELISA
  • Scl-70 ELISA
  • Sm ELISA
  • Specific Ige Calibrator 
  • Specific Ige Kit 
  • Specific IgG Elisa -Conjugate Elisa 
  • Specific IgG4 Elisa -Conjugate Kit
  • Total Ige
  • Total IgE-HRP EIA
  • Tryptase – ELISA i
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Information On Allergy

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Allergy is a common disease. A large part of the population of industrialized countries suffers from allergies and the number of affected people is rising steadily. According to the World Health Organization 20% of the world's population is affected by IgE-mediated allergic diseases1.

Immunoglobulin E (IgE) is mainly responsible for the development of allergies. The predisposition to suffer from allergy is called atopy. It describes an individual tendency to develop allergic diseases such as asthma, allergic rhinitis, eczema or dermatitis, conjunctivitis or even anaphylaxis/ anaphylactic shock.

It is well known that both environmental and genetic factors can lead to increased sensitivities against normal environmental proteins. Environmental factors include for example disproportionate hygiene, environmental pollution or repeated contacts with chemicals.

If an allergy occurs, general avoidance of allergens or medical treatment of the symptoms is often the only possibility to relieve the symptoms.

Allergy - What happens inside the body?
Allergy is an imbalance of the immune system. The body strongly reacts to, in fact, harmless substances. These substances are called allergens. An allergen is, according to the definition, a small molecule that provokes immune reactions. The list of possible allergens is still growing.

After allergen uptake, antigen presenting cells (APC) exhibit parts of this allergen on their surface to be recognized by T cells. The activated T cells subsequently stimulate B cells to produce antibodies directed to this certain allergen.

When the mast cells get bound by antibodies the mast cells get activated and release substances that can induce acute inflammation, bronchial asthma, urticaria or hay fever. These reactions occur within seconds or minutes depending on whether the allergen is already known to the body and if the specific antibodies still exist or not.

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Specific IgE

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Total IgE-HRP EIA

Allergic reactions of the immediate type (Type I allergies) are mediated by allergen specific Immunoglobulin of class E. The normal serum IgE concentration is age dependent with a peak at the age of 6-15 years. Mostly, the occurrence of allergen specific IgE is accompanied by increased titers of total IgE in the blood of the patients. In these cases the titer can increase up to 1000fold. Usually, IgE concentrations are determined in international units per millilitre (IU/mL) wherein 1 IU/mL corresponds to 2.4 ng of IgE. Highest IgE concentrations occur in patients with atopic dermatitis in which they often reach levels of 50.000 IU/mL. Moreover, increased titers of IgE can be observed in patients with parasitic diseases. Deviations to the normal values have also been described in patients with certain autoimmune disorders.

Intended Use This total IgE Test is intended for the quantitative determination of IgE in human serum or plasma. The results add to the diagnosis of type I allergies.Furthermore, determination of total IgE is recommended in patients with suspected parasitic diseases.

General features
  • CE labeled
  • User-friendly
  • Coloured reagents
  • Ready to use reagents (except calibrators and washing buffer)
  • Dilution of calibrators and patient samples on plate
  • Breakapart microtiter plates
Technical information
  • Assay time: < 1.5 h at RT
  • 20 µL serum or plasma per test
  • Detection System: HRP/TMB (OD450 nm/620 nm)
  • 6-point calibration (5, 20, 50, 100, 200, 1000 IU/mL) according to WHO 75/502
  • Wide measuring range (5 IU/mL-1000 IU/mL)
  • Detection limit 5 IU/mL
Assay performance
  • Good correlation to the ImmunoCAP®-System (Phadia) R = 0.95
  • Excellent lot to lot correlation R2> 0.95
  • Low intra- and inter-assay variation CV% < 10
  • Excellent correlation to Total IgE EIA (08100CP)
  • Excellent linearity over the entire range
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Specific IgE with biotinylated allergens

Diagnosis of allergy
There are some possibilities to examine the individual sensitization. The common diagnostic procedures for detection of IgE mediated allergy encompass the following tests: Skin prick test, Provocation - oral, conjunctival. nasal, bronchial, Blood test/ immunoassay.

An immunoassay allows quantifying the concentration of IgE antibodies (In total or allergen-specific antibodies).

The immunoglobulin E in the patients blood is bound to the monoclonal antibodies and specific allergens of the Specific IgE test. The concentration of IgE can be calculated. Levels of specific IgE that are higher than 0.35 IU/mL suggest that the patient has a sensitization.

For correct diagnosis of allergy the obtained results of specific IgE immunoassays have to be associated with clinical examinations, the case history of each patient and, if necessary, other test kinds.

Allergy is a common disease. A large part of the population of industrialized countries suffers from allergies and the number of affected people is rising steadily. According to the World Health Organization 20% of the world's population is affected by IgE-mediated allergic diseases.

Immunoglobulin E (IgE) is mainly responsible for the development of allergies. The predisposition to suffer from allergy is called atopy. It describes an Individual tendency to develop allergic diseases such as asthma, allergic rhinitis, eczema or dermatitis, conjunctivitis or even anaphylaxis/ anaphylactic shock.

It is well known that both environmental and genetic factors can lead to increased sensitivities against normal environmental proteins. Environmental factors include for example disproportionate hygiene, environmental pollution or repeated contacts with chemicals.

If an allergy occurs, general avoidance of allergens or medical treatment of the symptoms is often the only possibility to relieve the symptoms.

Allergy - What happens inside the body?
Allergy Is an Imbalance of the immune system. The body strongly reacts to, In fact, harmless substances. These substances are called allergens. An allergen is, according to the definition, a small molecule that provokes immune reactions. The list of possible allergens is still growing.

After allergen uptake, antigen presenting cells (APC) exhibit parts of this allergen on their surface to be recognized by T cells. The activated T cells subsequently stimulate B cells to produce antibodies directed cc this certain allergen.

When the mast cells get bound by antibodies, the mast cells get activated and release substances that can Induce acute inflammation, bronchial asthma, urticaria or hay fever. These reactions occur within seconds or minutes depending on whether the allergen is already known to the body and if the specific antibodies still exist or not.

 

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